The role of VEGF in the nervous system is extensive; apart from its angiogenic effect, VEGF has been described as a neuroprotective, neurotrophic and neurogenic molecule. Similar effects have been described for enriched environment (EE). Moreover, both VEGF and EE have been related to improved spatial memory. Our aim was to investigate the neurovascular and [...]
|
||||||
|
Microvascular environment plays a fundamental role in the adaptive response to increases in activity, involving an increase in energy demand. To punctual increases in demand, the response is effected by changes in local flow, but if demand remains high, angiogenic process is triggered through the formation of new capillaries from preexisting vessels. The triggering factor [...] Microvascular environment plays a fundamental role in the adaptive response to increases in activity, involving an increase in energy demand. To punctual increases in demand, the response is effected by changes in local flow, but if demand remains high, angiogenic process is triggered through the formation of new capillaries from preexisting vessels. The triggering factor [...] Postnatal development of the visual cortex is modulated by experience, especially during the critical period. Effects of vascular endothelial growth factor (VEGF) have been described in the neuronal, glial and vascular components of the neurogliovascular unit (1-4). In addition, VEGF is also involved in hippocampal-dependent learning. Similar effects have been demonstrated for enriched environments. Our [...] VEGF is the major angiogenic and vascular permeability factor in health and disease. Vascular development depends on function, and in sensory areas is experience-dependent. Our aim was to investigate, qualitatively and quantitatively, the effects of intracortical infusion and neutralisation of VEGF during the first days of the critical visual period, when peak levels of endogenous [...] The angiogenesis process is a key event for glioma survival, malignancy and growth. The start of angiogenesis is mediated by a cascade of intratumoural events: alteration of the microvasculature network; a hypoxic microenvironment; adaptation of neoplastic cells and synthesis of pro-angiogenic factors. Due to a chaotic blood flow, a consequence of an aberrant microvasculature, tissue [...] Microvascular environment plays a fundamental role in the adaptive response to increases in activity, involving an increase in energy demand. To puntual increases in demand, the response is effected by changes in local flow, but if demand remains high, angiogenic process is triggered through the formation of new capillaries from preexisting vessels. The trigger factor [...] Angioneurins are a family of molecules that include vascular growth factors such as VEGF, neurotrophins such as BDNF, IGF-I, and Erythropoietin, among others. They affect both neural and vascular processes. Due to the fact that all of them act over glia, we propose the term angioglioneurins to name them. They play a key role in [...] Brain postnatal development is modulated by experience. Experience-mediated changes increase neuronal activity leading to increased metabolic demands that involve adaptive changes including ones at the microvascular network. Trophic factors are crucial in CNS development and cell survival in adults. We have proposed the term Brain postnatal development is modulated by adaptation and experience. Experience-mediated changes increase neuronal activity leading to increased metabolic demands that involve adaptive changes including ones at the microvascular network. Therefore, vascular environment plays a key role in central nervous system (CNS) development and function in [...] |
||||||
|
ehusfera - UPV/EHUko blog zerbitzua - IKT Gerenteordetza - Vicegerencia de las TIC  |
||||||